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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Efferent projections from the paraventricular nucleus mediating alpha 2-noradrenergic feeding.

Feeding behavior elicited by central injection of the alpha-noradrenergic agonists, norepinephrine (NE) and clonidine (CLON), are believed to be mediated via postsynaptic alpha 2-type receptors located in the paraventricular nucleus (PVN). To map the course taken by essential efferent (descending) fibers of this PVN system for noradrenergically-stimulated feeding, the impact of diencephalic and lower brainstem coronal knife cuts, on the responses elicited by PVN-injected NE and CLON, was assessed. Rats that sustained damage in the periventricular gray area of the caudal thalamus and midbrain exhibited significant losses in feeding elicited by PVN injections of these drugs. In the case of animals with midbrain periventricular gray knife cuts, a significant increase in daily food intake was also observed, and this increase was positively correlated in magnitude with the attenuation of NE-induced feeding. This decrease in sensitivity to alpha 2-noradrenergic stimulation occurred with discrete periventricular knife cuts extending only 0.5 mm lateral to midline. In contrast, large ventral or lateral coronal knife cuts throughout the dorsal and ventral midbrain tegmentum left intact NE- and CLON-induced feeding. These findings provide evidence for localization of anatomical substrates which underlie PVN alpha 2-noradrenergic feeding. The efferent fibers of this system appear to exit from the PVN in a dorsomedial direction and course through the thalamic periventricular area. As this projection descends into the midbrain, it remains quite medial, maintaining this position throughout the midbrain central gray substance. At the level of the pons, just rostral to the locus coeruleus, this fiber projection appears to course ventrolaterally into the dorsolateral pontine tegmentum and possibly continue towards the dorsal vagal complex of the dorsomedial medulla.[1]

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