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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Influence of pentobarbital on effect and plasma levels of alprenolol and 4-hydroxy-alprenolol.

Six healthy subjects were given placebo and a single oral 0.2-gm dose of alprenolol (Aptin) before and after 0.1 gm pentobarbital at bedtime for 10 days. The plasma concentrations of alprenolol and its metabolite 4-hydroxy-alprenolol and the inhibition of exercise tachycardia were studied for 7 hr after the alprenolol. Alprenolol and 4-hydroxy-alprenolol plasma levels were decreased by about 40% by pentobarbital but plasma half-lives were unchanged. The inhibition of exercise tachycardia during a 7-hr period was reduced from 14.0% to 10.7% by pentobarbital. The reduction was proportional to the decreased drug plasma levels. There was a significant contribution of the metabolite to alprenolol effect. The estimation of relative potency of metabolite against parent compound was 0.9 before pentobarbital and 1.9 after pentobarbital.[1]

References

  1. Influence of pentobarbital on effect and plasma levels of alprenolol and 4-hydroxy-alprenolol. Collste, P., Seideman, P., Borg, K.O., Haglund, K., von Bahr, C. Clin. Pharmacol. Ther. (1979) [Pubmed]
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