The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

In vitro interaction of propanidid and suxamethonium with pooled human plasma cholinesterase. A kinetic study.

Human plasma cholinesterase (E.C. 3.1.1.8) was shown to be inhibited by physiological concentrations of propanidid and suxamethonium using a colourimetric assay at 25 degrees C and pH 7.2 unit with butyrylthiocholine as substrate. Propanidid inhibited the enzyme in a non-competitive manner (I50 = 2.0 mmol litre-1; apparent Km = 6.6 X 10(-4) mol litre-1) as did suxamethonium (I50 = 4.4 mmol litre-1; apparent Km = 1.6 X 10(-4) mol litre-1). Combined inhibition produced Km 3.0 X 10(-3) mol litre-1. The binding of these drugs to specific anionic sites in the vicinity of the active centre is thought to result in stereochemical changes in the enzyme. This mechanism and its relevance to the augmentation of the neuromuscular blockade produced by suxamethonium in the presence of propanidid is discussed.[1]

References

  1. In vitro interaction of propanidid and suxamethonium with pooled human plasma cholinesterase. A kinetic study. Taussig, P.E., Stojak, H.E., Bennett, N.R. British journal of anaesthesia. (1979) [Pubmed]
 
WikiGenes - Universities