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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane in the rat.

The soil fumigant 1,2-dibromo-3-chloropropane (I) undergoes hydrolysis in the rat to a series of epoxide metabolites. Alkylation of glutathione by these epoxides produces 2 urinary metabolites identified as the mercapturic acids VI (R=COCH3) and VII (R-COCH3). Hydrolysis of the epoxides produces the male antifertility agents alpha-chlorohydrin (IX, X-Cl) and alpha-bromohydrin (IX, X-Br) which are oxidatively metabolized to oxalic acid (XII), thus causing renal damage. These metabolic pathways can explain the toxic nature of the fumigant as a carcinogen, a male chemosterilant and as an agent causing kidney damage.[1]

References

  1. The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane in the rat. Jones, A.R., Fakhouri, G., Gadiel, P. Experientia (1979) [Pubmed]
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