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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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p-Chloroamphetamine antagonism of cobaltous chloride-induced hypothermia in mice.

Serotonin levels were measured in the brains of mice at 2 h and 10 days following the administration of a single dose of 10 mg/kg, i.p. of p-chloroamphetamine HCl (PCA). A 44% reduction in the concentration of brain serotonin was noted 2 h after PCA injection. No significant change in brain serotonin was observed 10 days following PCA administration. The time course of the body temperature response to cobaltous chloride (25 mg/kg, i.p.) was recorded 60 min following pretreatment with PCA (10 mg/kg, i.p.). PCA reduced the hypothermic response by approximately 60%, presumably through the depletion of central 5-hydroxytryptamine.[1]

References

  1. p-Chloroamphetamine antagonism of cobaltous chloride-induced hypothermia in mice. Burke, D.H., Brooks, J.C., Ryan, R.P., Treml, S.B. Eur. J. Pharmacol. (1979) [Pubmed]
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