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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cocaine: plasma concentrations after intranasal application in man.

Cocaine (1.5 milligrams per kilogram) was applied to the nasal mucosa of human subjects. The cocaine persisted in the plasma for 4 to 6 hours and reached peak concentrations of 120 to 474 nanograms per milliliter at 15 to 60 minutes. In that residual cocaine was detectable on the nasal mucosa for 3 hours, continuous absorption secondary to its vasoconstrictive action might explain its persistence in the plasma.[1]

References

  1. Cocaine: plasma concentrations after intranasal application in man. Van Dyke, C., Barash, P.G., Jatlow, P., Byck, R. Science (1976) [Pubmed]
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