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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.

The complete amino acid sequence of one of the polypeptide chains of the human T3/T-cell receptor complex, the T3 glycoprotein (T3-delta-chain) of relative molecular mass 20,000, was deduced from cDNA clones derived from HPB-ALL cells and a human T-cell clone. Inspection of the 171-amino acid sequence reveals a signal peptide, a 79-amino acid extracellular domain, one transmembrane region and a 44-amino acid intracellular domain which show no sequence homology with members of the T-cell receptor/immunoglobulin/ MHC multi-gene family. The T3 delta-chain is coded for by a single-copy gene the expression of which is restricted to T lymphocytes in humans and mice.[1]

References

  1. Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. van den Elsen, P., Shepley, B.A., Borst, J., Coligan, J.E., Markham, A.F., Orkin, S., Terhorst, C. Nature (1984) [Pubmed]
 
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