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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence.

Two cDNA clones encoding the predominant form of the asialoglycoprotein receptor from rat liver (the major rat hepatic lectin; RHL-1) were identified by screening a rat liver cDNA library with a mixed oligonucleotide probe 35 nucleotides long. One clone was a nearly full-length copy of the mRNA for RHL-1, while the other was shortened at both ends. The sequences of these clones demonstrate that this transmembrane receptor is not synthesized with an NH2-terminal signal sequence. The only proteolytic processing occurring in the biosynthesis of RHL-1 is the removal of the NH2-terminal initiator methionine residue. Insertion of RHL-1 into the membrane is postulated to occur by the recognition of the internal transmembrane region as a signal sequence.[1]

References

  1. Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence. Holland, E.C., Leung, J.O., Drickamer, K. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
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