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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone.

Heparin or a heparin fragment administered with cortisone inhibited angiogenesis, caused regression of large tumor masses, and prevented metastases. Oral administration of heparin resulted in the release of non-anticoagulant heparin fragments in the serum which, in the presence of cortisone, had similar anti-angiogenic and antitumor effects. Of all the heparin fragments tested, the most potent inhibition of angiogenesis in the presence of cortisone was provided by a hexasaccharide with a molecular weight of about 1600.[1]

References

  1. Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Folkman, J., Langer, R., Linhardt, R.J., Haudenschild, C., Taylor, S. Science (1983) [Pubmed]
 
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