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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Monoclonal antibodies to HLA recognize monomorphic and polymorphic epitopes on BoLA.

Fourteen monoclonal antibodies recognizing monomorphic and polymorphic epitopes on class I and class II antigens of the human MHC have been assayed on lymphocytes of a panel of 20-150 BoLA typed bovine animals from 12 different breeds. Some monomorphic antibodies cross-reacted and others did not. Two polymorphic monoclonal antibodies in man recognize a polymorphism in cows that follows allospecificities (BoLA-w3, w9) already described. Immunoprecipitation experiments with monomorphic anti-B2m and anti-HLA-DR monoclonal antibodies have shown that these cross-reactions concern BoLA antigens. They also revealed that Ia-like antigens in cattle present the same two chain features characterized in other species.[1]

References

  1. Monoclonal antibodies to HLA recognize monomorphic and polymorphic epitopes on BoLA. Chardon, P., Kalil, J., Leveziel, H., Colombani, J., Vaiman, M. Tissue Antigens (1983) [Pubmed]
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