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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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New approach to metabolism of 5'-deoxy-5-fluorouridine in humans with fluorine-19 NMR.

The metabolism of 5'-deoxy-5-fluorouridine (5'dFUrd), an antitumor fluoropyrimidine, has been investigated in human biofluids (blood, plasma, urine) using a new method: fluorine-19 NMR spectrometry. This method allows direct study of the biological sample and simultaneous identification of all the fluorinated metabolites. In the blood of a patient treated with 5'dFUrd during a 6-h continuous perfusion, we observed unmetabolized 5'dFUrd, 5-fluorouracil, 5,6-dihydrofluorouracil, and another metabolite which has not previously been reported alpha-fluoro-beta-alanine. The two major metabolites in urine are unmetabolized 5'dFUrd and alpha-fluoro-beta-alanine.[1]

References

  1. New approach to metabolism of 5'-deoxy-5-fluorouridine in humans with fluorine-19 NMR. Malet-Martino, M.C., Martino, R., Lopez, A., Béteille, J.P., Bon, M., Bernadou, J., Armand, J.P. Cancer Chemother. Pharmacol. (1984) [Pubmed]
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