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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Generation of BALB-MuSV and Ha-MuSC by type C virus transduction of homologous transforming genes from different species.

The nature of the cell-derived (bas) sequences of BALB-MuSV, a spontaneous mouse sarcoma virus isolate, was determined. Molecularly cloned bas sequences demonstrated no detectable homology with the onc genes of other mouse transforming viruses, but exhibited a high degree of sequence homology with the ras gene of the rat-derived Harvey murine sarcoma virus (Ha-MuSV) genome. The Ha-MuSV cell-derived sequence ( ras) shared a colinear 750 bp region of homology with bas. Moreover, BALB-MuSV transformation was associated with the expression of high levels of a 21,000 dalton protein, immunologically related to the ras gene products, p21. Thus bas and ras represent retroviral transforming gene homologs that were independently transduced by mouse type C viruses from the genomes of different species.[1]

References

  1. Generation of BALB-MuSV and Ha-MuSC by type C virus transduction of homologous transforming genes from different species. Andersen, P.R., Devare, S.G., Tronick, S.R., Ellis, R.W., Aaronson, S.A., Scolnick, E.M. Cell (1981) [Pubmed]
 
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