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Høstmark, J. et al.

The effect of 13-cis-retinoic acid on dibutylnitrosamine induced polyploidy changes in mouse urothelium.

The epithelium in the normal urinary bladder contains cells with diploid to octoploid DNA-content. The carcinogen dibutylnitrosamine (DBN), given subcutaneously in repeated doses causes a loss of polyploidy prior to cancer development. In this study the changes in polyploidy caused by DBN was followed by use of flow cytometry. 13-cis-retinoic acid did not prevent this loss of polyploidy, and did not affect the polyploidy in the normal urothelium.[1]

References

The effect of 13-cis-retinoic acid on dibutylnitrosamine induced polyploidy changes in mouse urothelium. Høstmark, J., Farsund, T. Anticancer Res. (1982) [Pubmed]

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