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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus.

The two murine retroviral restriction genes, Fv-4 and Akvr-1, are very similar in their effects, distributions, ranges of action, and phenotypes. Akvr-1 has been shown to segregate independently in backcrosses with a variety of retroviral restriction loci, including Fv-1, Fv-2, Ril-1, and Ril-2. An allelism test cross of FRG (Fv-4R) X LCRR (Akvr-1R) hybrids mated to AKR mice failed to produce any viremic offspring. These results suggested that Akvr-1R and Fv-4R are alleles of a single locus, Fv-4, on mouse chromosome 12.[1]

References

  1. Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus. O'Brien, S.J., Berman, E.J., Estes, J.D., Gardner, M.B. J. Virol. (1983) [Pubmed]
 
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