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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine.

The inhibition of herpes simplex virus type 1 plaque formation by acyclovir, bromovinyldeoxyuridine, 9-(3,4-dihydroxybutyl)guanine, and 9-(4-hydroxybutyl)guanine at different thymidine concentrations was analyzed in Lineweaver-Burk plots. Linear competitive patterns between thymidine and the nucleoside analogs were observed for the inhibition of herpes simplex virus type 1 plaque formation. A new constant, the reversal constant Kr, was introduced to describe the sensitivity in cell culture of an antiviral drug to the reversal of its viral activity by a metabolite (e.g., thymidine).[1]

References

  1. Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine. Larsson, A., Brännström, G., Oberg, B. Antimicrob. Agents Chemother. (1983) [Pubmed]
 
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