Biosynthesis of S-N6-methyladenosylhomocysteine, an inhibitor of RNA methyltransferases.
This paper demonstrates that N6-methyladenosine (6-methylaminopurine ribonucleoside) will condense in vitro with homocysteine to form S-N6-methyladenosylhomocysteine in a reaction catalyzed by mouse liver S-adenosylhomocysteine hydrolase. Injection of mice with N6-methyladenosine is followed by accumulation of S-N6-methyladenosylhomocysteine in the liver. Studies from other laboratories have shown that S-N6-methyladenosylhomocysteine is nearly as potent an RNA methyltransferase inhibitor as S-adenosylhomocysteine. This indicates that administration of N6-methyladenosine may be a general method for blocking in vivo RNA methylation in studies to determine the role of methylation in RNA processing and translational function.[1]References
- Biosynthesis of S-N6-methyladenosylhomocysteine, an inhibitor of RNA methyltransferases. Hoffman, J.L. J. Biol. Chem. (1978) [Pubmed]
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