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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Role of ornithine decarboxylase in cardiac growth and hypertrophy.

Inhibition of cardiac ornithine decarboxylase ( ODC) by alpha-difluoromethylornithine (DFMO) did not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced hypertrophy. Hypertrophy caused by triiodothyronine was not prevented by DFMO. There appear to be both ODC-dependent and ODC-independent processes contributing to the subcellular mechanisms associated with growth, which must be considered in the potential laboratory and clinical use of DFMO.[1]


  1. Role of ornithine decarboxylase in cardiac growth and hypertrophy. Bartolome, J., Huguenard, J., Slotkin, T.A. Science (1980) [Pubmed]
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