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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effects of chlorobenzenes on hepatic porphyrin and drug metabolism in chick embryo and day-old chick.

Administration of monochlorobenzene (MCB), p-dichlorobenzene (DCB), or 1,2,4-trichlorobenzene (TCB) at single doses of 800 mg/kg produced an increase in the total porphyrin content of liver of day-old chicks. Porphyrinogenic activity was higher in DCB- and TCB-treated chicks than in MCB-treated chicks. Administration of any of these compounds to chick embryos (40 mg/egg) failed to produce an induction of liver porphyrins. TCB enhanced the excretion of porphyrin in bile of chicks but not of chick embryos. In day-old chicks TCB increased hepatic cytochrome P-450 levels and the activity of 7-ethoxyresorufin deethylase. However, 7-ethoxycoumarin deethylase activity was decreased while cytosolic glutathione S-transferase activity was unchanged. These results point out the differential response of chick embryos and day-old chicks to chlorobenzene-induced changes in porphyrin metabolism as well as the differential induction of microsomal monooxygenases in chicks by TCB.[1]

References

  1. Effects of chlorobenzenes on hepatic porphyrin and drug metabolism in chick embryo and day-old chick. Miranda, C.L., Wang, J.L., Henderson, M.C., Nakaue, H.S., Buhler, D.R. Res. Commun. Chem. Pathol. Pharmacol. (1984) [Pubmed]
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