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Petranyi, G. et al.

Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase.

A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.[1]

References

Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Petranyi, G., Ryder, N.S., Stütz, A. Science (1984) [Pubmed]

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