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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Modulation of proline-rich protein biosynthesis in rat parotid glands by sorghums with high tannin levels.

Feeding of sorghum with a high level of tannin (high-tannin sorghum) to rats caused changes in gene expression in parotid glands similar to isoproterenol treatment. Within 3 days the parotid glands were enlarged about 3-fold and a series of proline-rich proteins were increased about 12-fold. Unlike isoproterenol treatment, no changes were observed in the submandibular glands, and a Mr 220,000 glycoprotein in parotid glands was not induced. Amino acid analyses, electrophoretic patterns, and cell-free translations of mRNAs all confirmed that the proline-rich proteins induced by feeding high-tannin sorghum were identical to those induced by isoproterenol treatment. Binding curves for proline-rich proteins to tannins showed affinities 10-fold greater than bovine serum albumin and tannins.[1]

References

  1. Modulation of proline-rich protein biosynthesis in rat parotid glands by sorghums with high tannin levels. Mehansho, H., Hagerman, A., Clements, S., Butler, L., Rogler, J., Carlson, D.M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
 
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