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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Clot-selective coronary thrombolysis with tissue-type plasminogen activator.

Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.[1]

References

  1. Clot-selective coronary thrombolysis with tissue-type plasminogen activator. Bergmann, S.R., Fox, K.A., Ter-Pogossian, M.M., Sobel, B.E., Collen, D. Science (1983) [Pubmed]
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