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Yamamoto, M. et al.

Translational inhibition by heme of the synthesis of hepatic delta-aminolevulinate synthase in a cell-free system.

Synthesis of delta-aminolevulinate synthase in a rabbit reticulocyte lysate system directed by total polysomes from the liver of allylisopropylacetamide-treated rats was studied with the combined use of [3H]leucine and a specific rabbit antibody. The protein synthesis observed in the cell-free system employed represented mainly the peptide chain elongation and its termination rather than the net synthesis involving initiation. Synthesis of delta-aminolevulinate synthase in this cell-free system was inhibited progressively with the increased addition of hemin; the synthesis was reduced to about 40% by about 30 microM hemin. Synthesis of total protein, however, was not significantly affected by the addition of hemin. The data obtained suggest that heme inhibits a peptide chain elongation step in the synthesis of delta-aminolevulinate synthase.[1]

References

Translational inhibition by heme of the synthesis of hepatic delta-aminolevulinate synthase in a cell-free system. Yamamoto, M., Hayashi, N., Kikuchi, G. Biochem. Biophys. Res. Commun. (1983) [Pubmed]

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