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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Plant antitumor agents, 19. Novel triterpenes from Maprounea africana.

Four new pentacyclic triterpenes have been isolated from Maprounea africana. These triterpenes are members of the previously unknown urs-12-en-29-oic acid series. The structures of these compounds were deduced from spectral and chemical evidence. The parent compound, maprounic acid, was identified as 3B-hydroxyurs-12-en-29-oic acid. The remaining three triterpenes were identified as maprounic acid 3-p-hydroxybenzoate, 7 beta-hydroxymaprounic acid 3-p-hydroxybenzoate, and 2 alpha-hydroxymaprounic acid 2,3-bis-p-hydroxybenzoate. Of the four triterpenes, only the 7 beta-hydroxy derivative exhibited in vivo P-388 activity.[1]

References

  1. Plant antitumor agents, 19. Novel triterpenes from Maprounea africana. Wani, M.C., Schaumberg, J.P., Taylor, H.L., Thompson, J.B., Wall, M.E. J. Nat. Prod. (1983) [Pubmed]
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