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Effect of electroconvulsive shock on muscarinic cholinergic receptors in rat cerebral cortex and hippocampus.

Single electroconvulsive shock (ECS) induced no change in [3H]quinuclidinyl benzilate ([3H]QNB) binding to muscarinic cholinergic receptors in rat cortex and hippocampus. ECS administered once daily for 7 days induced a significant reduction in [3H]QNB binding in both brain areas. Concurrent ECS reversed the significant increase in cortical [3H]QNB binding induced by chronic atropine administration. These findings may have relevance to the antidepressant or amnestic effects of electroconvulsive therapy.[1]

References

  1. Effect of electroconvulsive shock on muscarinic cholinergic receptors in rat cerebral cortex and hippocampus. Lerer, B., Stanley, M., Demetriou, S., Gershon, S. J. Neurochem. (1983) [Pubmed]
 
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