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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cimetidine dynamics after repeated intravenous injection.

Cimetidine dynamics were studied in six multiple-trauma patients receiving 300 to 600 mg every 6 hr for prevention of stress ulceration. Patients received cimetidine intravenously for a mean duration of 7.8 days. There was a positive correlation between cimetidine serum concentration and gastric pH; the correlation between intragastric cimetidine concentration and gastric pH was stronger. The association between therapeutic efficacy (pH greater than 4) and serum concentration over 1 mcg/ml was significant. The association with gastric cimetidine concentration above 2 mcg/ml was significant.[1]

References

  1. Cimetidine dynamics after repeated intravenous injection. Pancorbo, S., Bubrick, M.P., Chin, T.W., Miller, K.W., Onstad, G. Clin. Pharmacol. Ther. (1984) [Pubmed]
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