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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Metabolic cooperation between argininosuccinate synthetase and argininosuccinate lyase deficient human fibroblasts.

Human fibroblasts deficient in either argininosuccinate synthetase or argininosuccinate lyase show low levels of incorporation of [14C]citrulline into protein. However, when these two cell types are co-cultured [14C]citrulline incorporation is restored to the levels found in control cultures. This metabolic cooperation is cell-density-dependent and does not occur by diffusion of argininosuccinate into the medium. Our results indicate that argininosuccinate passes between the two cell types via intercellular junctions, and this system provides a simple and accurately quantifiable model for the study of intercellular communication.[1]

References

  1. Metabolic cooperation between argininosuccinate synthetase and argininosuccinate lyase deficient human fibroblasts. Davidson, J.S., Baumgarten, I.M., Harley, E.H. Exp. Cell Res. (1984) [Pubmed]
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