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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The effect of single doses of penbutolol and propranolol L.A. on psychomotor performance.

The effect of single oral doses of penbutolol (40 mg) and propranolol L.A. (160 mg) on psychomotor performance of 12 normal individuals has been investigated. Subjects were randomly administered penbutolol, propranolol L.A. and placebo according to a double-blind, three-part cross-over design. At 3 h post-dosing both penbutolol and propranolol L.A. significantly increased (P less than 0.001) complex reaction times when compared to placebo. By 24 h post-dosing the mean complex reaction times for penbutolol and propranolol L.A. were not significantly different from placebo.[1]

References

  1. The effect of single doses of penbutolol and propranolol L.A. on psychomotor performance. Broadhurst, A.D., Monaghan, A.T. British journal of clinical pharmacology. (1984) [Pubmed]
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