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Transdermal scopolamine, oral meclizine, and placebo in motion sickness.

The efficacy of transdermal scopolamine, oral meclizine, and placebo in protection against motion sickness was compared in a double-blind crossover study. Thirty-six healthy subjects were exposed to motion three times for 90 min in a ship-motion simulator. Transdermal applications were made and tablets were taken at least 12 and 2 hr before exposure to motion. Transdermal scopolamine provided better protection than placebo or meclizine. Dryness of mouth was the only side effect reported more frequently for one regimen, transdermal scopolamine.[1]


  1. Transdermal scopolamine, oral meclizine, and placebo in motion sickness. Dahl, E., Offer-Ohlsen, D., Lillevold, P.E., Sandvik, L. Clin. Pharmacol. Ther. (1984) [Pubmed]
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