Cytotoxic T-cell response to H-Y in 'non-responder' CBA mice.
Murine cytotoxic T-cell (Tc cell) responses to various antigens are controlled by immune response genes (Ir) mapping in the major histocompatibility complex ( H-2). Both helper T cells, controlled by I region-coded genes, and Tc cells, controlled by K/D antigens, are necessary for a positive response. An H-2-restricted Tc-cell response to the male specific minor transplantation antigen ( H-Y) can be elicited in B10 (H-2b) female mice primed with syngeneic male spleen cells intraperitoneally (i.p.) or intravenously (i.v.), or by skin grafting followed by restimulation in vitro in mixed lymphocyte culture ( MLR) with male cells. CBA (H-2k) mice do not respond by these routes of in vivo priming, and this was thought to be due to a lack of permissible Ir genes for helper function. However, we now report that subcutaneous hind-footpad (fp) immunisation of 'non-responder' CBA mice with syngeneic male cells changes them to responders, a result which argues against a generalised Ir gene-controlled helper defect.[1]References
- Cytotoxic T-cell response to H-Y in 'non-responder' CBA mice. Müllbacher, A., Brenan, M. Nature (1980) [Pubmed]
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