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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Gap junction development is correlated with insulin content in the pancreatic B cell.

The development of gap junctions between insulin-containing B cells was quantitatively analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked depletion of the insulin content of B cells and with an increase in the number and size of gap junctions between these cells. A significance correlation was found between these two events.[1]

References

  1. Gap junction development is correlated with insulin content in the pancreatic B cell. Meda, P., Halban, P., Perrelet, A., Renold, A.E., Orci, L. Science (1980) [Pubmed]
 
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