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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Isolation from bovine brain of a novel analgesic pentapeptide, neo-kyotorphin, containing the Tyr- Arg (kyotorphin) unit.

A novel analgesic peptide, isolated from the bovine brain, was found to contain the Tyr- Arg (kyotorphin) unit at the C-terminal portion. This peptide, in the methanol-soluble fraction, was isolated by gel filtration and cation exchange chromatography. This peptide was termed "neo-kyotorphin" and the amino acid sequence is Thr-Ser-Lys-Tyr-Arg. The synthetically prepared neo-kyotorphin proved to have a dose-dependent analgesic effect in mice. The median analgesic dose, ED50 of neo-kyotorphin was 195 nmol/mouse (intracisternal injection), with the tail pinch test, and the potency was approximately equal that of Leu-enkephalin.[1]

References

  1. Isolation from bovine brain of a novel analgesic pentapeptide, neo-kyotorphin, containing the Tyr-Arg (kyotorphin) unit. Fukui, K., Shiomi, H., Takagi, H., Hayashi, K., Kiso, Y., Kitagawa, K. Neuropharmacology (1983) [Pubmed]
 
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