The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Failure of filipin to detect cholesterol-rich domains in smooth muscle plasma membrane.

Using the cholesterol probe filipin and freeze-fracture electron microscopy, Montesano reported an apparent difference in cholesterol content between contiguous zones of the smooth muscle plasma membrane. In this membrane, microinvaginations termed caveolae are organized in band-like domains, which were highly sensitive to filipin (and therefore cholesterol-rich) compared with the surrounding non-caveolar inter-band regions (assumed to be cholesterol-poor). Using another cholesterol probe, the saponin tomatin, applied alone and after filipin treatment, we now present evidence that both the band and inter-band domains of the smooth muscle plasma membrane are cholesterol-rich. This leads to the conclusion that the lack of inter-band response to filipin is a false-negative cytochemical result.[1]

References

 
WikiGenes - Universities