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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake.

Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharin solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharin intake may cause increased release and utilization of endogenous opiates.[1]

References

  1. Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake. Lieblich, I., Cohen, E., Ganchrow, J.R., Blass, E.M., Bergmann, F. Science (1983) [Pubmed]
 
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