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Simpson, M. et al.

Dissolution kinetics of a three-component solid I: ethylparaben, phenacetin, and salicylamide.

The dissolution rates of each component in compressed spheres consisting of three components were measured under sink conditions. A film diffusion model is discussed and presented diagrammatically to illustrate the 13 possible dissolution behaviors of a three-component solid. Experimental dissolution rates compare favorably to dissolution rates calculated according to the model at mass fractions representative of the 13 dissolution behaviors.[1]

References

Dissolution kinetics of a three-component solid I: ethylparaben, phenacetin, and salicylamide. Simpson, M., Parrott, E.L. Journal of pharmaceutical sciences. (1983) [Pubmed]

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