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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Toxicity of penicillamine. A serious limitation to therapy in rheumatoid arthritis.

A retrospective study of penicillamine toxicity in 156 patients yielded a high incidence of toxic reaction (62%), necessitating discontinuation of the drug therapy in 36% of the patients. Of the total group, proteinuria occurred in 14%, hematologic toxic reaction in 11%, mucocutaneous toxic reaction in 28%, and gastrointestinal intolerance in 12%.[1]

References

  1. Toxicity of penicillamine. A serious limitation to therapy in rheumatoid arthritis. Halverson, P.B., Kozin, F., Bernhard, G.C., Goldman, A.L. JAMA (1978) [Pubmed]
 
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