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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Tolerability of ibuprofen and flurbiprofen in G-6-PD deficient subjects: in vitro study.

1 A 'GSH (reduced glutathione) stability test' which consists of incubating blood samples with acetylphenylhydrazine and other test drugs and measuring GSH level before and after incubation, was carried out. 2 Application of this test to the blood of eight normal volunteers and twelve known G-6-PD deficient persons demonstrated that acetylphenylhydrazine and primaquine produced a significant decrease in GSH levels in G-6-PD deficient red cells compared to the reduction seen in normal red cells incubated with these drugs. No such change was observed with aspirin, ibuprofen and flurbiprofen. 3 The results of this in vitro study seem to indicate that ibuprofen and flurbiprofen are relatively innocuous in G-6-PD deficient individuals.[1]

References

  1. Tolerability of ibuprofen and flurbiprofen in G-6-PD deficient subjects: in vitro study. Sheth, U.K., Valame, S.P., Gupta, K.C., Baxi, A.J., Kulkarni, V.N., Pispati, P.K. British journal of clinical pharmacology. (1981) [Pubmed]
 
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