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Honn, K.V. et al.

Prostacyclin: a potent antimetastatic agent.

Metastasis is the principal cause of failures to cure human cancers. Prostacyclin is a powerful antimetastatic agent against B16 amelanotic melanoma cells. This effect, which may result from the platelet antiaggregatory action of prostacyclin, is potentiated by a phosphodiesterase inhibitor. Inhibitors of prostacyclin synthesis increase metastasis. Prostacyclin and agents that may increase endogenous prostacyclin production or prolong its activity are suggested as new antimetastatic agents.[1]

References

Prostacyclin: a potent antimetastatic agent. Honn, K.V., Cicone, B., Skoff, A. Science (1981) [Pubmed]

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