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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Bronchoconstrictor effects of leukotriene C in humans.

Maximum expiratory flow rate at 30 percent of vital capacity above residual volume served as an index of airway obstruction in comparing the effects of leukotriene C and histamine administered by aerosol to five normal persons. Leukotriene C was 600 to 9500 times more potent than histamine on a molar basis in producing an equivalent decrement in the residual volume. The leukotriene C response was slow in onset and prolonged, reminiscent of the effects of aerosol allergen challenge in asthmatic allergic subjects.[1]

References

  1. Bronchoconstrictor effects of leukotriene C in humans. Weiss, J.W., Drazen, J.M., Coles, N., McFadden, E.R., Weller, P.F., Corey, E.J., Lewis, R.A., Austen, K.F. Science (1982) [Pubmed]
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