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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Failure of rats deprived of water to increase food intake during glucoprivation induced by 2-deoxy-D-glucose.

Thirsty rats denied access to water did not significantly increase their food intake following the glucoprivic stimulus provided by 750 mg/kg 2-deoxy-D-glucose (2-DG). In a second study, subjects were made hypodipsic through adulteration of their water supply with 0.2% w/v quinine hydrochloride; and they too displayed glucoprivic feeding deficits at 250 mg/kg, 500 mg/kg, and 750 mg/kg dosages. A reduced ability to ingest fluids therefore can inhibit 2-DG-induced eating when rats are examined after experience with water restriction schedules. These data consequently suggest that caution may be necessary in interpreting post-lesion disruptions of 2-DG glucoprivic feeding when severe water intake deficits are also observed.[1]

References

  1. Failure of rats deprived of water to increase food intake during glucoprivation induced by 2-deoxy-D-glucose. Watson, P.J., Biderman, M.D. Pharmacol. Biochem. Behav. (1982) [Pubmed]
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