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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibition of human erythrocyte and plasma cholinesterases by methamidophos.

Methamidophos (O, S-dimethyl phosphoramidothioate) inhibition of human erythrocyte and plasma cholinesterase was studied in vitro. The pseudo-biomolecular rate constant of inhibition was 3.14 +/- 0.22 X 10(3) M-1 min-1 for erythrocyte cholinesterase and 1.85 +/- 0.01 X 10(3) M-1 min-1 for plasma cholinesterase. Thus methamidophos, although quite toxic to mammals, is a slow, rather non-selective inhibitor of human cholinesterases, as was also observed previously in rats.[1]

References

  1. Inhibition of human erythrocyte and plasma cholinesterases by methamidophos. Robinson, C.P., Beiergrohslein, D. Journal of applied toxicology : JAT. (1982) [Pubmed]
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