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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Testosterone-estradiol binding globulin binds to 2-methoxyestradiol with greater affinity than to testosterone.

This report describes the unexpected observation that testosterone-estradiol binding globulin (TeBG) binds 2-methoxyestradiol better than it binds either testosterone or 17 beta-estradiol. As determined by competitive displacement of 3H-testosterone from TeBG adsorbed onto a solid phase matrix of Con A-Sepharose, the relative binding activities of 2-methoxyestradiol, testosterone and 17 beta-estradiol for TeBG were 2.0, 1.0 and 0.32, respectively. In contrast, 2-methoxyestradiol, which is known to bind with low affinity to estrogen receptors, had only low affinity binding to the androgen receptor, as determined by competitive displacement of 3H-dihydrotestosterone using 64-24 rat mammary tumor cells. 2-Methoxyestradiol is the first example of a naturally occurring steroid which binds with high affinity to TeBG but with low affinity to both androgen and estrogen receptors.[1]

References

  1. Testosterone-estradiol binding globulin binds to 2-methoxyestradiol with greater affinity than to testosterone. Dunn, J.F., Merriam, G.R., Eil, C., Kono, S., Loriaux, D.L., Nisula, B.C. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
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