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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Inhibition of 1-methyl-1-nitrosourea-induced mammary carcinogenesis in the rat by the retinoid axerophthene.

The hydrocarbon retinoid, axerophthene, and retinyl acetate were compared for their ability to prevent mammary cancer induced in rats by 1-methyl-1-nitrosourea. Chronic feeding of both retinoids delayed the appearance and lessened the incidence of cancers; retinyl acetate was definitely more active. However, axerophthene was significantly better tolerated by the rats and allowed normal weight gain when fed in high doses, in contrast to retinyl acetate.[1]

References

  1. Inhibition of 1-methyl-1-nitrosourea-induced mammary carcinogenesis in the rat by the retinoid axerophthene. Thompson, H.J., Becci, P.J., Moon, R.C., Sporn, M.B., Newton, D.L., Brown, C.C., Nürrenbach, A., Paust, J. Arzneimittel-Forschung. (1980) [Pubmed]
 
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