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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effect of adenosine versus adenine nucleotides on evoked potentials in a rat hippocampal slice preparation.

A marked depression of evoked CA1 potentials was observed with the nucleotide analogues a,b-methylene ADP (AOPCP) and adenylimido-diphosphate (AIP) and with 2'-adenosine monophosphate (2'-AMP). While the depression elicited by 5'-nucleotides was completely antagonized by the action of adenosine deaminase, AOPCP and 2'-AMP were only partially antagonized. The findings indicate that nucleotides on their own are capable of modulating synaptic transmission but that the physiologically more prevalent 5'-AMP is mediating its effect via adenosine. By producing this membrane permeable compound and allowing its re-uptake, the 5'-nucleotidase may determine the time course of purinergic action.[1]

References

  1. Effect of adenosine versus adenine nucleotides on evoked potentials in a rat hippocampal slice preparation. Lee, K.S., Schubert, P., Emmert, H., Kreutzberg, G.W. Neurosci. Lett. (1981) [Pubmed]
 
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