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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Comparison of induction of sister chromatid exchange, 8-azaguanine- and ouabain-resistant mutants by cyclophosphamide, ifosfamide and 1-(pyridyl-3)-3,3-dimethyltriazene in Chinese hamster cells cultured in diffusion chambers in mice.

Data on induction of sister chromatid exchange (SCE), 8-azaguanine and ouabain-resistant mutants in V79 cells in diffusion chambers in mice treated with three chemicals were compared to determine the relationship between SCE and mutation. For 1-(pyridyl-3)-3,3-dimethyltriazene, a positive, linear correlation was demonstrated between induced SCE and mutation at both loci. For cyclophosphamide and ifosfamide, it was observed that SCE analysis was a more sensitive biological endpoint than induction of mutation.[1]

References

  1. Comparison of induction of sister chromatid exchange, 8-azaguanine- and ouabain-resistant mutants by cyclophosphamide, ifosfamide and 1-(pyridyl-3)-3,3-dimethyltriazene in Chinese hamster cells cultured in diffusion chambers in mice. Sirianni, S.R., Huang, C.C. Carcinogenesis (1980) [Pubmed]
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