Interactions between intracranial electrical self-stimulation behavior and cardiovascular responses.
Interactions between electrical self-stimulating behavior, cardiovascular state and reactions were studied in a series of chronically prepared cats. Pressor responses were found to be the most common cardiovascular concomitants of intracranial electrical self-stimulating behavior in cats. The lever-pressing rate for brain stimulation decreased under the effect of both dibenzyline, an adrenergic blocking agent, and local anesthesia of the cervical vago-sympathetic trunk by procaine. Bilateral vagotomy resulted in an acceleration in lever-pressing responses. The depression and the acceleration in the lever-pressing for brain stimulation were associated with an increase and a decrease in pulse pressure, respectively. It is suggested that peripheral autonomic modifications exert a regulatory feedback effect on the rewarding property of brain stimulation.[1]References
- Interactions between intracranial electrical self-stimulation behavior and cardiovascular responses. Angyán, L. J. Auton. Nerv. Syst. (1981) [Pubmed]
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