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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Simultaneous determination of misonidazole and desmethylmisonidazole in plasma by high-performance liquid chromatography.

A high-performance liquid chromatographic method for the simultaneous determination of misonidazole and desmethylmisonidazole in plasma is described. After plasma is deproteinized with methanol and the diluted supernatant is chromatographed on a C18 reversed-phase column, both compounds are quantitated by means of an internal standard. The coefficients of variation of within-day and day-to-day precision are below 5.0% for misonidazole in the concentration range of 25-250 mg/l and below 6.1% for desmethylmisonidazole in the concentration range of 2.5-25.0 mg/l. Calibration curves are linear and an analytical recovery varying from 97.6 to 99.8% is obtained. The detection limits for misonidazole and desmethylmisonidazole in plasma are 1.4 mg/l and 0.7 mg/l, respectively.[1]

References

  1. Simultaneous determination of misonidazole and desmethylmisonidazole in plasma by high-performance liquid chromatography. Meering, P.G., Maes, R.A. J. Chromatogr. (1981) [Pubmed]
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