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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.

1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2-thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances.[1]

References

  1. The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients. Skellern, G.G., Knight, B.I., Low, C.K., Alexander, W.D., McLarty, D.G., Kalk, W.J. British journal of clinical pharmacology. (1980) [Pubmed]
 
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