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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension.

Hyperparathyroidism and hyperaldosteronism coexisted in association with medullary sponge kidneys in a 27-year-old woman with severe hypertension. A modest fall in systolic and diastolic pressure followed removal of a parathyroid adenoma. Blood pressure was controlled with spironolactone therapy and restored to normal after removal of an aldosterone-secreting adrenal tumor. Elevated levels of aldosterone may have been responsible for the severe hypertension, while hypercalcemia may have had a synergistic effect on the arteriolar response to circulating vasoactive peptides.[1]

References

  1. Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension. Hellman, D.E., Kartchner, M., Komar, N., Mayes, D., Pitt, M. JAMA (1980) [Pubmed]
 
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