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Gómez-Jiménez, J. et al.

Clinical efficacy of mild analgesics in pain following gynaecological or dental surgery: report on multicentre studies.

1 Dipyrone 1.0 g, paracetamol 1.0 g and placebo were compared in a double-blind parallel group study in patients with episiotomy pain. 2 Patients were stratified according to severity of initial pain (severe or moderate) and the three treatments were randomized for each of these two groups. 3 Two-hundred and sixty-four patients entered the study: five patients were excluded from analysis; 127 patients had 'severe' pain, 132 'moderate' pain. 4 Both drugs were more effective than placebo, and dipyrone was significantly more effective than paracetamol, particularly where initial pain was severe. 5 The efficacy of dipyrone 1.0 g was compared with paracetamol 1.0 g in relieving pain after tooth extraction. 6 Ninety patients entered the study and 87 were analyzed without stratification according to initial pain severity. 7 Dipyrone was consistently and significantly more effective than paracetamol at every assessment.[1]

References

Clinical efficacy of mild analgesics in pain following gynaecological or dental surgery: report on multicentre studies. Gómez-Jiménez, J., Franco-Patino, R., Chargoy-Vera, J., Olivares-Sosa, R. British journal of clinical pharmacology. (1980) [Pubmed]

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