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Bakker, H.J. et al.

Experimental induction of ovine polioencephalomalacia.

Polioencephalomalacia (PEM) was induced in sheep, with an overall incidence of 63 per cent, using local bracken fern (Pteridium esculentum) rhizomes as a source of thiaminase type 1 and pyridine as a basic cosubstrate. The condition was thiamin responsive and PEM was confirmed by histopathological examination. In a separate experiment to examine the effect of pyridine, it was shown that, for the duration of the experiment, pyridine had no toxic effect and caused no histologically detectable brain lesions.[1]

References

Experimental induction of ovine polioencephalomalacia. Bakker, H.J., Dickson, J., Steele, P., Nottle, M.C. Vet. Rec. (1980) [Pubmed]

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